Human MRP14 ELISA Kit 출시
LEGEND MAX™ Human MRP14 ELISA Kit
Cat No. 445307, 445308
Standard Range : 313-20,000 pg/mL
63.1 pg/mL ± 34.6 pg/mL (mean ± 2 SD; n=9)
Kit Contents :
Anti-Human MRP14 Pre-coated 96-well Strip Microplate
Human Cystatin C Dectection Antibody
Human Cystatin C Standard
Assay Buffer D
Wash Buffer (20X)
Substrate Solution F
Migration inhibitory factor-related protein 14 (MRP14), also known as S100 Calcium-Binding Protein A9 (S100A9) and calgranulin B, is a 14 kD member of the S100 family, which is a group of calcium-binding proteins that regulate intra- and extracellular activities of other effector proteins, enzymes, receptors, cytoskeletal subunits, and nucleic acids. MRP14 consists of 114 amino acids and is expressed in granulocytes, monocytes, macrophages, and tumor cells. This protein predominantly forms heterodimers (known as calprotectin) and heterotetramers with MRP8 (S100A8), but also can form homodimers.
Human MRP14 shares significant amino acid sequence identity with MRP14 from other species, including >79%, 72%, 70%, 68%, 64%, and 57% from non-human primates, equine, bovine, porcine, rat, and mouse, respectively.
MRP14 has major roles as an inflammatory mediator. It regulates myeloid cell function by binding to Toll-like receptor-4 and the receptor for advanced glycation end-products (RAGE). MRP14 induces neutrophil chemotaxis and adhesion, promotes phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2, and induces degranulation of neutrophils by a MAPK-dependent mechanism. MRP14 is a potential biomarker for many diseases as it plays important roles in inflammatory disorders and autoimmune diseases, and has been implicated in carcinogenesis and acute myocardial infarction.
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