In this Webinar, You Will Learn:
• How type 2 immune responses are controlled in barrier tissues
• Novel tools to investigate the initiation of type 2 immunity
• Role of tissue-specific dendritic cells in the induction of type 2 immunity
• Implications of tissue-specific control of type 2 immunity
About this Webinar:
To maintain an immunological balance and an intact epithelial barrier many tissues display a prominent anti-inflammatory pro-type 2 immune environment that can rapidly expel and entrap multicellular pathogens, neutralize toxins and support wound healing. Based on the unique physiological requirements of each barrier tissue, these responses are however specialized and induced by different populations of dendritic cells.
Previous research has shown that KLF4-expressing type 2 dendritic cells (cDC2) are drivers of enhanced type 2 immunity and present a high degree of phenotypic and functional heterogeneity in different tissues, suggesting that they adapt to diverse peripheral environments.
Using high-dimensional proteomic and single-cell RNA-sequencing technologies, we could show that cDC2 exhibit unique signatures in different murine tissues at the steady state. Focusing on the developmental requirements of these subsets we could show that CD11b-low cDC2, a population uniquely found in skin, required STAT6- and KLF4-dependent IL-13 signaling, whereas cDC2 subsets in lung and small intestine were STAT6-independent, with similar observations made in human skin.
In turn, analysis of healthy murine and human skin revealed low levels of type 2 cytokine production by innate lymphoid cells, Dendritic Epidermal T Cells and memory T cells. In healthy murine skin, IL-13, but not IL-4, was necessary and sufficient for the development of CD11b-low dendritic cells, suggesting a type 2 associated signaling circuit between type 2 cytokines, CD11b-low cDC2 and Th2 priming. In the absence of IL-13 signaling, dermal dendritic cells were stable in number and continued to take up antigen, but remained CD11b-hi. CD11b-hi dendritic cells furthermore showed defective activation in response to parasite antigens and a diminished ability to support IL-4+ GATA3+ Th2 cell differentiation.
Low levels of type 2 cytokines in healthy tissues might therefore play an important role in dendritic cell reprogramming and the generation of an anti-inflammatory pro-type 2 immune environment, which protects against multicellular pathogens but might also contribute to the development of allergies.
In this webinar, you will learn:
- How type 2 immune responses are controlled in barrier tissues
- Novel tools to investigate the initiation of type 2 immunity
- Role of tissue-specific dendritic cells in the induction of type 2 immunity
- Implications of tissue-specific control of type 2 immunity
Time: Tuesday, June 18, 2024 CEST 10:00 / IST 13:30 / JST & KST 17:00 (Time is friendly to our Asia-Pacific customers.)
MCE Webinar Page: https://www.medchemexpress.com/webinar-Johannes.html
Zoom Registration Link: https://us06web.zoom.us/webinar/register/WN_qXHC8CDqTSWjHslgCXAb-Q#/registration
Also, you can use this link to download these materials: https://www.dropbox.com/scl/fo/q32rz2hmgai5htpkzw27n/AOudVIQp_PsuU2Q9uw560cM?rlkey=8emunfiko47edwc37rd3b29tg&st=zpj8s4jw&dl=0